Trends in Clinical and Medical Sciences

Special issue: Recent developments of medical and surgical research (2023), pp. 204 – 209
ISSN: 2791-0814 (online) 2791-0806 (Print)
DOI: 10.30538/psrp-tmcs2023.si-rdmsr027

Comparative study of sublingual misoprostol (PGE1) versus intracervical dinoprostone (PGE2) for induction of labour in nulliparous postdated pregnancy

Swopna Susmita Majhi\(^{1}\), Mahija Sahu\(^{2}\), Shantisena Mishra\(^3\), Saroj Shekhar Rath\(^4\) and Swapna Mahapatra\(^{5,*}\)
\(^{1}\) Junior Resident, Department of Obstretics & Gynecology, MKCG Medical College, Berhampur, Odisha, India.
\(^2\) Professor, Department of Obstretics & Gynecology, MKCG Medical College, Berhampur, Odisha, India.
\(^3\) Professor, Department of Pediatrics, Bhima Bhoi Medical College Balangir Odisha, India.
\(^4\) Associate Professor, Department of Pediatrics, MKCG Medical College Berhampur. Odisha, India.
\(^5\) Assistant Professor, Department of Pharmacology, MKCG Medical College, Berhampur, Odisha, India.
Correspondence should be addressed to Swapna Mahapatra at swapnamahapatra1@gmail.com

Copyright © 2023 Swopna Susmita Majhi, Mahija Sahu, Shantisena Mishra, Saroj Shekhar Rath and Swapna Mahapatra. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: January 20, 2023 – Accepted: March 15, 2023 – Published: April 16, 2023

Abstract

Objective: To compare the efficacy of sublingual misoprostol tablet and intracervical dinoprostone gel for induction of labour in nulliparous postdated pregnancy and assess the maternal and fetal outcome after induction.
Methodology: It is a prospective randomized controlled study conducted over a period of 2 years (nov 2020 to nov 2022), in dept. of obstetrics and gynecology, mkcg mch. Out of 200 cases 100 cases were given sublingual misoprostol tablet (Group 1) and rest were given intracervical dinoprostone gel (Group 2). The efficacy of both the drugs were assessed by favorability of Bishop’s score at 24 hours, need of augmentation with oxytocin, drug administration to delivery interval, mode of delivery, APGAR score, NICU admission, maternal complication and number of failed induction, data was analyzed description statistics and chi square test.
Result: Mean Drug administration to delivery interval was shorter and significant (18. 53hours vs 20.42) hours, p-value 0.0018). Need for augmentation (48 vs 65, p-value 0.0125), failed induction rate (5 vs 11), post-delivery mean blood loss( 436.50mL vs 516 mL, p value- 0.0173) were significantly lower with misoprostol group. NICU admission was lower in dinoprostone group (7 vs 14).
Conclusion: Sublingual misoprostol tablet is efficacious in inducing labour, with shorter drug administration to induction interval, and higher vaginal delivery rate as compared to dinoprostone gel.

Keywords:

Dinoprostone gel; Misoprostol tablet; Induction of labour; Drug administration to delivery interval.