Trends in Clinical and Medical Sciences
Special issue: Recent developments of medical and surgical research (2023), pp. 432 – 439
ISSN: 2791-0814 (online) 2791-0806 (Print)
DOI: 10.30538/psrp-tmcs2023.si-rdmsr060
ISSN: 2791-0814 (online) 2791-0806 (Print)
DOI: 10.30538/psrp-tmcs2023.si-rdmsr060
A comparative study to evaluate the efficacy of intranasal midazolam and intranasal dexmedetomidine as pre-medication in paediatric patients
Monika Gandhi\(^{1}\), Gireesh Tyagi\(^{2,*}\), Shailendra Singh\(^{3}\) and K. K. Arora\(^{4}\)
\(^{1}\) Professor, Department of Anaesthesiology, Mahatma Gandhi Memorial Medical College, Indore, Madhya Pradesh, India. \\
\(^{2}\) Postgraduate Resident, Department of Anaesthesiology, Mahatma Gandhi Memorial Medical College, Indore, Madhya Pradesh, India.
\(^{3}\) Assistant Professor, Department of Emergency Medicine, Mahatma Gandhi Memorial Medical College, Indore, Madhya Pradesh, India.
\(^{4}\) Professor & Head, Department of Anaesthesiology, Mahatma Gandhi Memorial Medical College, Indore, Madhya Pradesh, India.
Correspondence should be addressed to Gireesh Tyagi at tyagigireesh1990@gmail.com
Copyright © 2023 Monika Gandhi, Gireesh Tyagi, Shailendra Singh and K. K. Arora. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: March 20, 2023 – Accepted: May 1, 2023 – Published: May 5, 2023
Abstract
This study aimed to compare the efficacy of Midazolam and Dexmedetomidine as premedication agents in pediatric patients administered via the intranasal route. 100 children in ASA physical status I and II, aged 2-8 years, planned for surgery under general anesthesia, were randomly assigned to Group D, which received 1 mcg/kg of Intranasal dexmedetomidine, or Group M, which received 0.2 mcg/kg of Intranasal midazolam for premedication. The patients’ sedation status, separation anxiety, and mask acceptance were evaluated using UMSS, PSAS, and MAS, respectively, along with hemodynamic parameters and side effects. The mean sedation score was higher in Group D than Group M, and the mean parental separation anxiety score and mean mask acceptance score were also higher in Group D than Group M. All hemodynamic parameters were comparable and stable in both groups. In conclusion, intranasal dexmedetomidine was found to provide better sedation, relieve preoperative anxiety, make parental separation easier, and promote better mask acceptance, without any significant side effects.
Keywords:
Pediatric anesthesia; Premedication; Dexmedetomidine; Midazolam; Intranasal administration.