Efficacy of packed red cell transfusion in nutritional anemia patients in a rural tertiary care centre: A cross sectional study

TCMS-Special issue: Recent developments of medical and surgical research (2023), pp. 634 – 641 Open Access Full-Text PDF
Dr. Sriram Vijayaraghavan, Dr. Govindasamy Revathi, Dr. V. Vigneswaramoorthi, Dr. Erli Amel Ivan and Dr. Ramya Gandhi

Abstract:Background: Nutritional anemia is the commonest type of anemia in India, especially in rural areas. Patients with hemoglobin below 6 gm/dl usually require transfusion therapy. In stabilized patients with hemoglobin values between 6 and 10 gm/dl, the decision to transfuse is based on an evaluation of clinical status. Patients with values above 10 gm/dl rarely require transfusion. Initially, whole blood was transfused due to the activity of 2,3 DPG. However, now it is replaced by packed red cells after the advent of proper refrigeration, component separation method, and anticoagulants, especially additive solution SAGM and polyvinyl chloride blood bags.
Aims: 1) To know the efficacy of packed red cell transfusion in symptomatic nutritional anemia patients. 2) If there is a failure of improvement following packed red cells transfusion, the underlying cause of anemia will be evaluated, which may influence the outcome of the transfusion.
Materials and Methods: The present study comprised 110 nutritional anemia patients who received packed red cell transfusion in Sri Manakula Vinayagar Medical College and Hospital. Data were collected for eight months. A thorough clinical examination and history were taken for all 110 patients, and hematological parameters were collected from the automated cell counter.
Results: In the present study, 110 patients with nutritional anemia who underwent packed red cell transfusion were taken. Out of which, 90 patients had features of only iron deficiency anemia, and 20 had features of anemia of combined deficiency (iron, vitamin B12, and folic acid). Iron deficiency anemia is more prevalent in the third and fourth decades. Anemia of combined deficiency in the sixth and seventh decade. Conclusion: Packed red cell transfusions are reserved for anemia patients whose organs (brain, heart) are being deprived of oxygen due to severe anemia and for people whose hemoglobin or hematocrit level is very low. In chronic anemia, there are increases in the content of 2,3-DPG in the red blood cells, with a shift towards the right in the hemoglobin dissociation curve in the cardiac output and respiratory rate. Hence transfusion is rarely indicated. The mean increase in Hb and PCV values in nutritional anemia patients was statistically more significant (p value<0.05). Hence Hb and PCV can be valuable tools in post-transfusion clinical assessment.

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Study of the association of COVID-19 infection in the treatment outcomes in patients of rhino orbital Mucormycosis presenting to a tertiary care center

TCMS-Special issue: Recent developments of medical and surgical research (2023), pp. 624 – 633 Open Access Full-Text PDF
Sachin S Nilakhe, Shashikant N Dorkar and Indranil Basu

Abstract:Background: During the second wave of COVID-19 starting in January 2021, an increase in Mucormycosis infection was recorded in various Indian states. With the aim of identifying the contribution or relationship of covid 19 infection in the incidence, severity and treatment outcomes of Mucormycosis during the pandemic, this retrospective observational research study was conducted.
Method: 113 people with rhino orbital Mucormycosis were included in the retrospective observational investigation. Based off the past medical records, basic demographic information was gathered. In order to evaluate the association between covid 19 infection and Mucormycosis, patient histories of COVID infection, steroid usage during therapy, and oxygen consumption were collected. Positive RTPCR and/or Positive Rapid antigen tests were used to diagnose active covid positive status. Using a nasal swab/tissue KOH mount, nasal endoscopy with biopsy, and radiographic tests to determine the extent, the diagnosis of Mucormycosis infection was established. A multidisciplinary strategy was used to handle the patients in collaboration with the departments of medicine, ophthalmology, neurosurgery, and OMFS. Individuals with uncontrolled diabetes received insulin and/or oral medications, and BSL was aggressively managed. Each patient received 3 to 5 mg/kg body weight/day of intravenous amphotericin B, adjusted according to renal function, medication availability, and the severity of the illness. Individuals who underwent endoscopic debridement using a modified Denker’s technique or medial maxillectomy had disease that was restricted to the nose and paranasal sinuses but did not affect the palate or orbit. Whole maxillectomy was performed on patients who had palatal involvement. Most individuals with orbital involvement underwent a limited procedure for orbital decompression or rarely an exenteration/evisceration procedure.
Results: Out of 113 patients, 26 (23%) had a Covid positive status at the point they were initially assessed, 56 (49.55%) had confirmed prior h/o covid infection, 31 (27.4%) had no proven h/o covid 19 infection, and 62 (54%) had h/o usage of steroids to treat their covid infection. Of of the 113 patients, 90 patients underwent combination medicinal and surgical therapy, which comprised of administering injectable Amphotericin B and performing endoscopic endonasal debridement of the afflicted areas. 23 patients (20%) were left unoperated, largely as a result of problems arising from active COVID-19 infection (15 patients, 13%) or severe cerebral involvement (6 patients), as well as the refusal of two patients undergo surgery. Out of the 113 patients who received treatment, 24 (21.23%) died from the disease, leaving 89 (78.76%) surviving. Of the survivors, 27 (23.89%) had some form of disability at the end of the treatment period (in form of cranial nerve palsies, permanent loss of vision, palatal perforations and in 1 case a patient had an open left maxillary and nasal cavity which was referred to plastic surgeon for revision surgery and rehabilitation and 62 patients (54.86%) healed fully without any sequelae. Those who received combination therapy, which included both surgery and IV amphotericin, fared far better (84 in 90 survived 93%) than those who had only IV amphotericin B therapy (5 in 23 survived 22%).
Conclusion: Covid positive status was linked to higher disease severity, increased morbidity, and increased mortality after therapy. There were several individuals with Mucormycosis who had no prior history of COVID. Increased mortality was linked to uncontrolled diabetes, Rhino orbital cerebral expansion, and concurrent covid positive status. Our study shows that invasive Mucormycosis can have a positive clinical result with immediate vigorous surgical debridement and antifungal drug administration.

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Comparative study of serum beta-hCG between gestational hypertension and normotensive pregnant women at a tertiary care hospital in Kashmir

TCMS-Special issue: Recent developments of medical and surgical research (2023), pp. 618 – 623 Open Access Full-Text PDF
Shayesta Rahi, Nasir Rashid Dar, Shylla and Irshad Ahmad Kumar

Abstract:Introduction: Hypertensive disorders in pregnancy lead to placental immaturity and uteroplacental under-perfusion, resulting in increased production of beta-hCG hormone. The aim of this research is to compare beta-hCG levels after the 20th week of pregnancy between normotensive and hypertensive pregnant women in order to assess its predictive value for hypertensive conditions during pregnancy.
Material and Methods: This cross-sectional study was conducted in the Department of Obstetrics and Gynaecology, Govt. Medical College, Srinagar over a period of 18 months (January 2021 to July 2022). One hundred patients fulfilling the selection criteria were included in the study and divided into two groups (cases and controls). The data was collected in Excel Sheets and analyzed using SPSS v20.
Results: A total of 109 patients were included in our study, out of which 9 patients were lost to follow-up and were omitted from the study. Among the 100 patients, 50 were cases and 50 were controls based on the inclusion and exclusion criteria. In our study, mean systolic and diastolic blood pressure, mean gestational age, mean beta hCG, and proteinuria were statistically significant. However, mean beta hCG values based on PIH (Pregnancy-Induced Hypertension) severity and mean age were statistically insignificant.
Conclusion: In our study, we concluded that hypertensive pregnant women have abnormally elevated beta hCG levels.

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Complete hydatidiform mole with hook effect and severe anemia in 36-week size uterus: A rare case report from India

TCMS-Special issue: Recent developments of medical and surgical research (2023), pp. 614 – 617 Open Access Full-Text PDF
Rahul Kumar M. Padval, Vrajesh A. Shah, Sita K. Chaudhary and Ruchit V. Shah

Abstract:We present a rare case of a 27-year-old woman with a complete hydatidiform mole, which is an abnormal pregnancy that typically causes vaginal bleeding and elevated serum \(\beta\)-human chorionic gonadotrophin (hCG) levels. However, this patient had a 36-week size uterus, severe anemia, and vaginal bleeding, but with a non-detectable \(\beta\)-hCG level, likely due to the “hook effect.” She also had chronic pancreatitis, with a dilated hepatobiliary system and free fluid in the pelvis, caused by the enlarged uterus compressing the abdominal organs. The patient received blood transfusions and was treated with dilation, evacuation, and serial monitoring of serum \(\beta\)-hCG levels. It is important to note that a negative urine pregnancy test or non-detectable \(\beta\)-hCG level should be followed up with a repeat measurement on a diluted sample to avoid the “hook effect.”

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Effectiveness of dexmedetomidine as an adjuvant on hemodynamic parameters and recovery profile of patients undergoing sitting position intracranial tumour surgeries with desflurane as maintenance agent: A randomized prospective comparative double blinded study

TCMS-Special issue: Recent developments of medical and surgical research (2023), pp. 607 – 613 Open Access Full-Text PDF
Srilaxmi Rao, Deepa Shriyan and Kedar Mahajan

Abstract:Background: We aimed to study the influence of low dose dexmedetomidine as an adjuvant on hemodynamic parameters and recovery profile of patients maintained on desflurane for sitting position intracranial tumor surgeries.
Method: 60 ASA class I to III patients undergoing elective sitting position intracranial tumor surgery were randomized to receive either Dexmedetomidine infusion at the rate of 0.25 \(\mu\)g/kg/hr (Group D) or normal saline infusion (Group C) from the time patient was taken on table and continued till the end of dura closure. Monitoring done for hemodynamic changes, minimum alveolar concentration, BIS, recovery endpoints and adverse events.
Result: The heart rate was comparable in both the groups at baseline and decreased significantly in patients of Group D. The mean MAC in patients of Group C was high. The Bispectral Index values decreased significantly in patients of Group C as compared to Group D till the end of the study. The recovery endpoints parameters were significantly lower in patients of Group D as compared to patients of Group C. Ramsay Sedation Score was significantly lower in Group D compared to Group C from the time of discontinuation of anesthesia delivery till the end of 120 mins. This difference was statistically significant as per Student t-test (p<0.05).
Conclusion: Dexmedetomidine infusion started in low dose before surgery maintains hemodynamic stability intraoperatively, reduces the amount of anaesthetic drug required for induction, decreases the requirement of analgesic drug without any residual sedation.

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Stress among undergraduate students: Prevalence, sociodemographic associations and risk factors

TCMS-Special issue: Indian Medical Research Views and Findings on Last 5 years (2023), pp. 420 – 428 Open Access Full-Text PDF
Anish Jojo Philip, Lovely S Livingston, Rose Mary Thomas, Aakash K P and Ajay B Pillai

Abstract:Introduction: Stress among undergraduate students has become a significant concern in higher education due to its detrimental effects on their health and academic performance. This study aims to investigate the prevalence of stress among students pursuing their undergraduate education in a college in Kerala. By exploring the association between various sociodemographic variables and stress levels and identifying the relationship between different risk factors and stress, this research aims to provide valuable insights into the factors contributing to stress among undergraduate students.
Materials and Methods: A cross-sectional study was conducted among 133 undergraduate students. Convenience sampling was utilized to select the participants. A pre-designed closed-ended questionnaire, specifically tailored for this study, was employed to collect data. The questionnaire consisted of relevant items related to stress experienced by undergraduate students. Appropriate statistical analyses were performed on the collected data, with a significance level set at p < 0.05.
Results: The findings of this study revealed that among the study participants, 19% of undergraduate students experienced high perceived stress, 67% experienced moderate stress, and 13% experienced low-stress levels. A statistically significant association was observed between reduced appetite and perceived stress (p-value = 0.014). Additionally, statistically significant associations were found between stress and poor relationships with faculties (p-value = 0.003), the warden (p-value = 0.01), family members (p-value = 0.003), facing time pressure (p-value = 0.006), heavy workloads (p-value = 0.029), fear of failure (p-value = 0.002), suffering from frequent exams (p-value = 0.003), and exam patterns and curriculum (p-value = 0.024).
Conclusion: The results of this study highlight the considerable prevalence of stress among undergraduate students, with the majority falling into the category of moderate stress levels. It is imperative to prioritize undergraduate students’ mental and physical well-being by incorporating counseling services and preventive mental health programs as integral components of routine clinical services. Encouraging students to engage in regular physical exercise, maintain balanced nutrition, foster positive relationships with peers, family, faculty, and college staff, ensure adequate sleep, and participate in extracurricular activities can significantly reduce stress levels. By addressing these factors, educational institutions can foster a supportive learning environment that promotes undergraduate students’ overall health and well-being.

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Prospective study of the single puncture laparoscopic tubal ligation

TCMS-Special issue: Indian Medical Research Views and Findings on Last 5 years (2023), pp. 416 – 419 Open Access Full-Text PDF
Nagesh Shrirampant Nagapurkar, Swati Nagesh Nagapurkar and Khan Amreen Kausar

Abstract:Objective: To evaluate the demographic data such as age, parity, living male child, educational status, intraoperative, and postoperative complications of laparoscopic tubal ligation by single puncture method.
Methods: A prospective study of Laparoscopic Tubal Ligation was conducted at a medical college during 2016-2022. A total of 1060 cases were enrolled based on criteria, and Laparoscopic Tubal Ligation was performed under sedation plus local anesthesia. The procedure was done after 1st trimester MTP, during the interval, and the puerperal period.
Result: Most of the patients (79.67%) were in the age group of 22-30 years. 53.38% were para 2. Out of the total, 97.24% of women had 2 or more living children, while only 2.76% had only one living child. Similarly, 97.24% had 1 or more male child, and only 2.76% had no male child. During the procedure, 3 (0.28%) patients had uterine perforation, and one (0.9%) had Mesosalpinx hematoma that required laparotomy. Additionally, 3 (0.28%) patients had serous and blood discharge from the wound, 4 (0.37%) had wound gaping, and 1 (0.9%) had omental prolapse. None of the patients developed peritonitis, bowel injury, or required laparotomy at a later stage. Further study and follow-up are required to comment on the failure rates.
Conclusion: The associated factors with single puncture laparoscopic tubal ligation include age, parity, number of living children, male child, complications, and timing of surgery.

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A study of association of cystitis to SARS-CoV-2 infection in a tertiary care health facility

TCMS-Special issue: Indian Medical Research Views and Findings on Last 5 years (2023), pp. 410 – 415 Open Access Full-Text PDF
Dr. Benu Panigrahy, Dr. Y Roja Ramani, Dr. Swapna Mahapatra and Dr. Saroj Sekhar Rath

Abstract:Introduction: Since December 31st, 2019, SARS-CoV-2 infection (COVID-19) has affected individuals in various ways. During this pandemic, a notable increase in patients presenting with symptoms such as frequency, urgency, burning sensation, hematuria, fever with chills, with or without minimal Influenza-like Illness (ILI), who later tested positive for COVID-19, has been observed. Hemorrhagic cystitis is the most common presenting symptom of viral urinary tract infection (UTI), and some COVID-19 survivors have presented with recurrent hemorrhagic cystitis. These observations prompted us to evaluate the risk factors and association of hemorrhagic cystitis with COVID-19 patients.
Methods: A prospective observational study was conducted among patients presenting with symptoms of cystitis in an outpatient department.
Results: Socio-demographic and clinical characteristics, laboratory and radiological findings were collected, compiled, and analyzed using SPSS ver. 17.0. Out of 152 patients with cystitis, 96 had ILI and subsequently tested positive for COVID-19, and 20 had recovered from COVID-19 in the past month. Hematuria was found as the presenting symptom in 90 (59.21%) patients, with 78 (86.67%) testing positive for COVID-19 and 12 (13.33%) testing negative. According to the Droller et al. grading system, 49% had grade 1 severity, and 32% had grade 2 severity. Diabetes was the most significant risk factor associated with hemorrhagic cystitis.
Conclusion: This study clearly demonstrates an increased prevalence of and association with hemorrhagic cystitis in COVID-19 patients in this tertiary care center. Therefore, routine investigations in SARS-CoV-2 infected cases, such as urine cytology, upper tract imaging, and cystoscopy, will aid in the early diagnosis and proactive management of COVID-19-associated cystitis.

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A study of prescription pattern among COPD patients in a tertiary care hospital

TCMS-Special issue: Indian Medical Research Views and Findings on Last 5 years (2023), pp. 403 – 409 Open Access Full-Text PDF
Dr. Sachin Parmar, Dr. Sarita Jalodiya, Dr. Ritesh Churihar, Dr. Pawan Kumar Maurya and Dr. Nirmala Kushwaha

Abstract:Background: Irrational prescribing practices have a negative impact on the health and economy of individuals and society as a whole, resulting in resource wastage and widespread health hazards. The aim of this study was to analyze the drug prescribing pattern in patients with Chronic Obstructive Pulmonary Disease (COPD).
Methods: This prospective study included outpatients with COPD. Various parameters were recorded, including patient age, gender, outpatient ID number, occupation, smoking history, alcohol consumption, disease condition details, co-existing diseases, and prescribed medication details. The drug selection was assessed based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. Data was collected using a specially designed data entry form and tabulated. The results were expressed as percentages.
Results: The prescription data of 72 patients were analyzed in this study, comprising 58 males (80.56%) and 14 females (19.44%), with a mean age of 55.95 years. The male-to-female ratio was 4.14:1. Out of the total 72 patients, 62 (86.11%) were smokers, with 25 (40.32%) currently smoking and 37 (59.68%) being ex-smokers. Hypertension was the most common comorbidity, present in 35 (48.61%) patients. Inhalation was the most common route of drug administration in the study, followed by the oral route. The most frequently prescribed drugs were Formoterol (LABA) in 58 (81.56%) patients, Budesonide in 54 (75%), Acebrophylline in 44 (61.11%), while Terbutaline was the least used in 7 (9.72%) patients and Methylprednisolone in 6 (8.33%) patients.
Conclusion: The data revealed a low utilization of monotherapies, specifically long-acting muscarinic antagonist (LAMA), and a high utilization of combination therapies, particularly those containing inhaled corticosteroids (ICS). The drug prescribing pattern analysis aims to provide feedback and create awareness about appropriate medicine use.

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Radiological assessment of the posterior tibial slope as a risk factor for osteoarthritis of the knee in Indian population

TCMS-Special issue: Indian Medical Research Views and Findings on Last 5 years (2023), pp. 397 – 402 Open Access Full-Text PDF
Dr. S K Saidapur, Dr. P. Sai Srinivas, Dr. Sarang Shete, Dr. Ajeet Hundekar and Dr. R S Jatti

Abstract:Background: Osteoarthritis (OA) is a chronic degenerative disorder that affects the joints, causing pain and stiffness. Its prevalence in India ranges from 22% to 39%. Considering the increasing life span and the burden it imposes on individuals and society, early detection or prediction of OA in high-risk groups is crucial for implementing preventive measures. Several risk factors, including weight, genetic factors, sex, previous traumas, occupational factors, physical activity, lifestyle, and age, are associated with osteoarthritis. The geometry of the articular surface may also play a significant role, especially in the sagittal plane. The posterior tibial slope (PTS), defined as the posterior inclination of the tibial plateau in relation to its longitudinal axis in the lateral view, is a determinant of altered joint biomechanics. However, there is a lack of studies examining the correlation between the PTS angle and the risk of knee osteoarthritis in the Indian population. This study aims to determine the value of, and confirm the association between changes in posterior tibial slope observed on radiographs and osteoarthritis.
Materials and Methods: After obtaining ethical approval, 153 individuals visiting the outpatient department were selected based on inclusion and exclusion criteria. Demographic parameters such as age, sex, weight, height, co-morbidities, and medications were recorded. Knee examination findings, pain assessment using the Visual Analog Scale (VAS), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were documented. Knee joint radiographs, including anteroposterior (AP) and lateral views, were examined for patients with early OA (Kellgren-Lawrence Grade I and II). The posterior tibial slope was measured by determining the angle between the tangent to the tibial plateau and the perpendicular direction to the Tibial Shaft Anatomical Axis (TSAA).
Results: The study included 153 individuals with early osteoarthritic knees (Grade I and II). The mean posterior tibial slope measured in our study was found to be 11.5 with a standard deviation of 1.34. The range of PTS in our study was between 7\(^o\) and 13\(^o\).
Conclusion: Our study reveals that the posterior tibial slope in patients with early osteoarthritis was higher compared to the known normal values in the Indian population, suggesting an increased posterior tibial slope in individuals with osteoarthritic degeneration. Therefore, the posterior tibial slope can be used as a marker for screening osteoarthritis and initiating appropriate early interventions.

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