Trends in Clinical and Medical Sciences
Special issue: Indian Medical Research Views and Findings on Last 5 years (2023), pp. 355 – 361
ISSN: 2791-0814 (online) 2791-0806 (Print)
DOI: 10.30538/psrp-tmcs2023.si-imrv054
ISSN: 2791-0814 (online) 2791-0806 (Print)
DOI: 10.30538/psrp-tmcs2023.si-imrv054
An evaluation of plasma paraoxonase-1 (PON-1) levels in young and middle-aged patients with type-2 diabetes mellitus
Fozia Jamal\(^{1,*}\), Dr. Shikha Saxena\(^{2}\) and Dr. P.C. Srivastava\(^{3}\)
\(^{1}\) Ph.D. scholar, Department of Biochemistry, Rohilkhand Medical College and Hospital, Bareilly International University, Bareilly (Uttar Pradesh), India.
\(^{2}\) Professor and HOD, Department of Biochemistry, Rohilkhand Medical College and Hospital, Bareilly International University, Bareilly (Uttar Pradesh), India.
\(^{3}\) Professor and HOD, Department of Forensic Medicine, Rohilkhand Medical College and Hospital, Bareilly International University, Bareilly (Uttar Pradesh), India.
Correspondence should be addressed to Fozia Jamal at foziajamal101@gmail.com
Copyright © 2023 Fozia Jamal, Dr. Shikha Saxena and Dr. P.C. Srivastava. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: October 25, 2022 – Accepted: May 5, 2023 – Published: May 20, 2023
Abstract
Objectives: There is a lot of evidence that oxidative stress plays a role in the etiology of aging. PON-1 is mostly complexed to HDL and is responsible for its antioxidant properties. This investigation was undertaken to assess age-dependent changes in plasma PON-1 concentration and its association with age, HDL, BMI, and duration of diabetes among T2DM patients.
Methods: This study was carried out on 125 clinically diagnosed T2DM patients (young and middle-aged) attending the OPD and IPD of Rohilkh and Medical College and Hospital. Laboratory investigations such as fasting plasma glucose (FPG), HbA1c, and plasma PON-1 were measured.
Results: When compared with young patients, middle-aged patients showed a significantly declined plasma PON-1 (p < 0.01) and HDL (p < 0.05) levels and increased BMI (p < 0.05). The young and middle-aged patients showed a negative correlation of PON-1 with BMI (p < 0.01), duration of diabetes (p < 0.01), and a positive correlation with HDL (p < 0.01). However, only middle-aged diabetic patients showed a significant correlation of PON-1 with FPG (p < 0.01) and HbA1c (p < 0.01).
Conclusion: Decreased PON-1 concentration in middle-aged patients might be due to a decrease in HDL levels as a consequence of oxidative stress since PON-1 is mainly complexed to HDL.
Methods: This study was carried out on 125 clinically diagnosed T2DM patients (young and middle-aged) attending the OPD and IPD of Rohilkh and Medical College and Hospital. Laboratory investigations such as fasting plasma glucose (FPG), HbA1c, and plasma PON-1 were measured.
Results: When compared with young patients, middle-aged patients showed a significantly declined plasma PON-1 (p < 0.01) and HDL (p < 0.05) levels and increased BMI (p < 0.05). The young and middle-aged patients showed a negative correlation of PON-1 with BMI (p < 0.01), duration of diabetes (p < 0.01), and a positive correlation with HDL (p < 0.01). However, only middle-aged diabetic patients showed a significant correlation of PON-1 with FPG (p < 0.01) and HbA1c (p < 0.01).
Conclusion: Decreased PON-1 concentration in middle-aged patients might be due to a decrease in HDL levels as a consequence of oxidative stress since PON-1 is mainly complexed to HDL.
Keywords:
Plasma PON-1; Ageing; Diabetes mellitus type-2; Oxidative stress.