Trends in Clinical and Medical Sciences
Special issue: Indian Medical Research Views and Findings on Last 5 years (2023), pp. 329 – 333
ISSN: 2791-0814 (online) 2791-0806 (Print)
DOI: 10.30538/psrp-tmcs2023.si-imrv050
ISSN: 2791-0814 (online) 2791-0806 (Print)
DOI: 10.30538/psrp-tmcs2023.si-imrv050
Comparative study of hematological parameters in patients presenting with typhoid fever
Dr. Harsha Gajjar\(^{1}\), Dr. Rugvi Patel\(^{2}\), Mahla Shrideviben Gamanbhai\(^{3}\) and Patel Prachi Hitendrakumar\(^{4,*}\)
\(^{1}\) Assistant Professor, Department of Pathology, Narendra Modi Medical College, Ahmedabad, Gujarat.
\(^{2}\) Senior Resident, Department of Pathology, Narendra Modi Medical College, Ahmedabad, Gujarat.
\(^{3}\) Second Year Resident, Department of Pathology, Narendra Modi Medical College, Ahmedabad, Gujarat.
\(^{4}\) First Year Resident, Department of Pathology, Narendra Modi Medical College, Ahmedabad, Gujarat.
Correspondence should be addressed to Patel Prachi Hitendrakumar at prachi02101997@gmail.com
Copyright © 2023 Dr. Harsha Gajjar, Dr. Rugvi Patel, Mahla Shrideviben Gamanbhai and Patel Prachi Hitendrakumar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: October 21, 2022 – Accepted: May 5, 2023 – Published: May 20, 2023
Abstract
Background and Aim: Due to the etiological agent, Salmonella enterica serovar typhi (S.Typhi), enteric fever is a potentially lethal multisystemic disease. Leukopenia is considered a key feature of Enteric fever, but studies have shown it to be present in only 20-25% of cases. The aim of the present study was to determine specific hematological changes in typhoid fever.
Material and Methods: There were 300 individuals overall, who had typhoid fever clinical diagnosis. 150 patients were chosen as the case group and 150 as the control group out of the total. Blood samples were taken and analysed in a medical hospital for various haematological parameters as well as the Widal test in 300 patients with clinical suspicion of typhoid fever.
Results: In around one-third of cases, anorexia and abdominal pain were also observed. The least common symptoms were headache and diarrhoea. In patients who tested positive for typhoid, anaemia was present in 32% of cases, leukocytosis predominated over leukopenia, and thrombocytopenia affected roughly 24% of cases, which was significantly higher than the control group’s rate.
Conclusion: Our research led us to the conclusion that men get typhoid fever more frequently than women. And this can be explained by the fact that male subjects exhibit higher levels of the predisposing factors that lead to typhoid fever; this is likely due to their occupational and social practises, which tend to give male subjects greater immunity to this infection than do female subjects. Typhoid fever also tends to infect those who are uneducated and of poor socioeconomic position. Significant haematological alterations occur in people with typhoid fever.
Material and Methods: There were 300 individuals overall, who had typhoid fever clinical diagnosis. 150 patients were chosen as the case group and 150 as the control group out of the total. Blood samples were taken and analysed in a medical hospital for various haematological parameters as well as the Widal test in 300 patients with clinical suspicion of typhoid fever.
Results: In around one-third of cases, anorexia and abdominal pain were also observed. The least common symptoms were headache and diarrhoea. In patients who tested positive for typhoid, anaemia was present in 32% of cases, leukocytosis predominated over leukopenia, and thrombocytopenia affected roughly 24% of cases, which was significantly higher than the control group’s rate.
Conclusion: Our research led us to the conclusion that men get typhoid fever more frequently than women. And this can be explained by the fact that male subjects exhibit higher levels of the predisposing factors that lead to typhoid fever; this is likely due to their occupational and social practises, which tend to give male subjects greater immunity to this infection than do female subjects. Typhoid fever also tends to infect those who are uneducated and of poor socioeconomic position. Significant haematological alterations occur in people with typhoid fever.
Keywords:
Typhoid fever; Haemotological examination; Symptoms, Control group.