Paraquat-induced acute kidney injury in hospitalized patients in western orissa: clinical profile and long-term outcome

Due to the lack of effective therapies, therapeutic care such as medicines and early hemodialysis is viewed as the major kind of supportive care for paraquat poisoning. The aim of our present study was to evaluate acute kidney injury and its impact on various clinical parameters, including length of hospital stay, episodes of hemodialysis, number of ICU admissions, and mortality rates. This prospective observational study was launched after receiving approval from the Institutional Ethics Committee. All patients with acute renal injury caused by paraquat were admitted to the ward of the Department of General Medicine, VIMSAR, Burla, and included in the present study after obtaining informed written consent from each participant. The results showed that serum phosphorus and uric acid were highly significant (P < 0.001) when compared to laboratory features based on clinical outcomes, followed by alanine aminotransferase (ALP; P = 0.006), serum bicarbonate (P = 0.007), and serum potassium (P = 0.009). In conclusion, paraquat poisoning has no cure, but clinicians can monitor vital statistics and laboratory changes from diagnosis onward to understand the disease’s trajectory. It is recommended that the government prohibit the widespread distribution of this pesticide and inform the public about its toxicity.