Trends in Clinical and Medical Sciences
Special issue: Indian Medical Research Views and Findings on Last 5 years (2023), pp. 75 – 80
ISSN: 2791-0814 (online) 2791-0806 (Print)
DOI: 10.30538/psrp-tmcs2023.si-imrv012
ISSN: 2791-0814 (online) 2791-0806 (Print)
DOI: 10.30538/psrp-tmcs2023.si-imrv012
To study the levels of glucose and lipid profiles in metabolic syndrome and non-metabolic syndrome individuals
Abdul Rab Alli1\(^{1}\), Dr. Shreya Nigoskar\(^{2}\) and Doddigarla Zephy\(^{3,*}\)
\(^{1}\) Ph. D. Scholar, Department of Biochemistry, Index Medical College and Research Centre, Malwanchal University, Indore.
\(^{2}\) Professor and Head of the Department, Department of Biochemistry, Index Medical College and Research Centre, Malwanchal University, Indore.
\(^{3}\) Associate Professor, Department of Biochemistry, Hi-Tech Medical College and hospital, Rourkela.
Correspondence should be addressed to Doddigarla Zephy at zephy50@yahoo.com
Copyright © 2023 Abdul Rab Alli1, Dr. Shreya Nigoskar and Doddigarla Zephy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: March 3, 2023 – Accepted: May 12, 2023 – Published: May 14, 2023
Abstract
Background: The increased risk of cardiovascular disease and type II diabetes is attributed to the cluster of metabolic abnormalities known as metabolic syndrome. Most people with metabolic syndrome also have several other metabolic problems, including high blood sugar, insulin resistance, abnormal lipid profiles, and high blood pressure.
Aim: This study’s objective was to investigate the relationships between insulin, glucose, homeostasis metabolic assessment-estimated insulin resistance (HOMA-IR), and lipids in persons with metabolic syndrome.
Material and Methods: All the study participants consented. Control volunteers were 100 age- and gender-matched healthy volunteers. Second cohort: 100 metabolic syndrome patients treated. Same-age as well as gender normal-glycemic controls were used as the non-metabolic syndrome group. Each cohort was designated as normal if Body Mass Index (BMI) was (18.5-24.9 kg per m2), overweight (25-29.9 kg per m2), or obese (30 kg per m2).
Results: There was a statistically significant variation between 2 groups in terms of hemoglobin A1c (HbA1c), fasting blood sugar (FBS), and insulin mean values. Figure 1 displays the average levels of TC and triacylglycerols (TAGs) in patients having metabolic syndrome and in healthy control subjects. Serum weight measurements were found to be significantly varied between 2 groups. Metabolic syndrome sufferers had a mean TAGs level that was somewhat elevated compared to the control group, although they were still only around 40% higher than the norm.
Conclusion: Research along these lines is encouraged since it will lead to molecular insights that will help doctors control hyperglycemia and slow the development of related diseases. Open cholecystectomy cases can be done under thoracic epidural anaesthesia with 0.5% bupivacaine and buprenorphine or fentanyl as an adjuvant. Buprenorphine having prolong duration of analgesia can be better than fentanyl even in postoperative period.
Aim: This study’s objective was to investigate the relationships between insulin, glucose, homeostasis metabolic assessment-estimated insulin resistance (HOMA-IR), and lipids in persons with metabolic syndrome.
Material and Methods: All the study participants consented. Control volunteers were 100 age- and gender-matched healthy volunteers. Second cohort: 100 metabolic syndrome patients treated. Same-age as well as gender normal-glycemic controls were used as the non-metabolic syndrome group. Each cohort was designated as normal if Body Mass Index (BMI) was (18.5-24.9 kg per m2), overweight (25-29.9 kg per m2), or obese (30 kg per m2).
Results: There was a statistically significant variation between 2 groups in terms of hemoglobin A1c (HbA1c), fasting blood sugar (FBS), and insulin mean values. Figure 1 displays the average levels of TC and triacylglycerols (TAGs) in patients having metabolic syndrome and in healthy control subjects. Serum weight measurements were found to be significantly varied between 2 groups. Metabolic syndrome sufferers had a mean TAGs level that was somewhat elevated compared to the control group, although they were still only around 40% higher than the norm.
Conclusion: Research along these lines is encouraged since it will lead to molecular insights that will help doctors control hyperglycemia and slow the development of related diseases. Open cholecystectomy cases can be done under thoracic epidural anaesthesia with 0.5% bupivacaine and buprenorphine or fentanyl as an adjuvant. Buprenorphine having prolong duration of analgesia can be better than fentanyl even in postoperative period.
Keywords:
Metabolic syndrome; Homeostasis Model Assessment of Insulin Resistance (HOMA-IR); Hyperglycemia; Insulin; Insulin resistance.