Trends in Clinical and Medical Sciences

Special issue: Recent developments of medical and surgical research (2023), pp. 367 – 371
ISSN: 2791-0814 (online) 2791-0806 (Print)
DOI: 10.30538/psrp-tmcs2023.si-rdmsr050

A study on role of autologous platelet rich fibrin matrix in treatment of non-healing ulcer

Dr. Lachhaman Bag\(^1\), Dr. Sibaram Panda\(^2\), Dr. Saroj Shekhar Rath\(^3\), Dr. Sworupa Nanda Mallick\(^{4,*}\), Dr. Saroj Kumar Sethi\(^5\) and Dr. Upasana Das\(^6\)
\(^{1}\) Assistant Professor Department of General surgery, PRM Medical college, Baripada, Odisha, India.
\(^2\) Senior Resident, Department of Dermatology, PRM Medical college, Baripada, Odisha, India.
\(^3\) Associate Professor, Department of Pediatrics, M.K.C.G, Medical College & Hospital, Berhampur, Ganjam, Odisha, India.
\(^4\) Assistant Professor, Department of General Surgery, M.K.C.G, Medical College & Hospital, Berhampur, Ganjam, Odisha, India.
\(^5\) Associate Professor Department of General surgery, PRM Medical college, Baripada, Odisha, India.
\(^6\) Assistant Professor, Department of Pathology, PRM Medical college, Baripada, Odisha, India.
Correspondence should be addressed to Dr. Sworupa Nanda Mallick at drsworup@gmail.com

Copyright © 2023 Dr. Lachhaman Bag, Dr. Sibaram Panda, Dr. Saroj Shekhar Rath, Dr. Sworupa Nanda Mallick, Dr. Saroj Kumar Sethi and Dr. Upasana Das. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: December 7, 2022 – Accepted: April 20, 2023 – Published: April 29, 2023

Abstract

Non-healing ulcers can cause significant health problems and impair quality of life. Standard treatment procedures have been found to be ineffective in curing such lesions. Autologous platelet-rich fibrin matrix (PRFM) has been cited in many research papers as an effective treatment for non-healing ulcers. This study aims to evaluate the efficacy of PRFM in treating chronic non-healing ulcers. A prospective study was conducted in patients with trophic ulcers due to Hansen’s disease or diabetes mellitus, traumatic ulcers, and venous ulcers, aged between 18-85 years. PRFM was applied to healthy ulcers at weekly intervals, repeated for a maximum of five sittings as per requirement. Photographs were taken before treatment and at every subsequent sitting, and area and volume were calculated at baseline and every subsequent sitting until closure was achieved. The results of the study will help to determine the efficacy, feasibility, and cost-effectiveness of PRFM in the treatment of non-healing ulcers.

Keywords:

Non-healing ulcers; Autologous platelet-rich fibrin matrix (PRFM); Efficacy; Chronic wounds; Treatment.