Comparative study of oral native collagen type 2 versus oral glucosamine sulphate in patients with grade 2 and grade 3 primary osteoarthritis of the knee

Background: Osteoarthritis (OA) is a degenerative joint disease that affects the cartilage and surrounding tissues. This study aimed to compare the efficacy of oral native collagen type 2 and oral glucosamine sulphate in patients with grade 2 and grade 3 primary knee osteoarthritis.
Materials and Methods: This was a randomized observational prospective study conducted on patients aged 30 years or above, of any gender, diagnosed with primary knee osteoarthritis of grade 2 and 3. The patients were randomly assigned to two groups using computer randomization software. Group 1 received native type 2 collagen 40 mg (Tablet Dupact 40 mg, Wockhardt Limited), while Group 2 received oral glucosamine 1500 mg (Lubrijoint 750 mg twice daily).
Results: The majority of participants in the Glucosamine group were in the 51-60 years age group (32.5%), while the majority in the Collagen group were slightly younger, belonging to the 41-50 years age group (30%). The mean age of the Glucosamine group (57.2 \(\pm\) 10.45 years) was similar to the Collagen group (57.2 \(\pm\) 11.39 years), and the difference was not statistically significant. The pre-treatment and post-treatment (after 12 weeks) C-reactive protein (CRP) values did not show a statistically significant difference between the two groups. However, both the Glucosamine and Collagen treatments resulted in a significant reduction in WOMAC score and visual analog scale (VAS) score over the course of the 12-week treatment.
Conclusion: Both Glucosamine and Collagen treatments showed improvements in reducing painful and swollen joints, as well as significant improvements in VAS and WOMAC scores.